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Celecoxib attenuated ZD-promoted colon tumorigenesis through suppressing pro-inflammatory mediators. (A) Effect of celecoxib on tumor number (n=15). (B) Effect of celecoxib on tumor incidence (n=15). (C) Effect of celecoxib on mRNA expression of IL1β, IL6, CCL2, CXCL2, and CXCL5 (n=6). (D) Effect of celecoxib on protein level of IL1β and CXCL5 (n=6). Data are showed as means ±SEM. *P < 0.05, **P < 0.01 and *** P < 0.001 vs ZS groups. #P < 0.05 and ##P < 0.01 vs ZD + celecoxib group.
