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. 2021 Mar 10;13(6):8797–8816. doi: 10.18632/aging.202688

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Copyright: © 2021 Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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DEcircRNA/DElncRNA-miRNA-DEmRNA crosstalk network. Through linear regression model analysis and seed sequence matching method based on gene expression, five DEcircRNAs and seven DElncRNAs were established as a regulatory network of miRNA sponge adsorbents. (A–E) The network of five verified circRNAs (mmu_circ_0000233 (A), mmu_circ_0015035 (B), mmu_circ_0012936 (C), mmu_circ_0008393 (D) and cicRNA.20127 (E)). (F–L) The network of seven verified lncRNAs (NONMMUT132168 (F), NONMMUT127961 (G), NONMMUT132160 (H), ENSMUST00000204847 (I), NONMMUT024778 (J), NONMMUT109267 (K) and ENSMUST00000194077 (L)). Red rhombi: up-regulated DEcircRNAs. Green rhombi: down-regulated DEcircRNAs. Red squares: up-regulated DElncRNAs. Green squares: down-regulated DElncRNAs. Gray V: miRNAs. Red circles: up-regulated DEmRNAs. Green circles: down-regulated DEmRNAs.