TABLE I.
Materials used in engineered brain-mimetic platforms. PEG: polyethylene glycol; PLLA: poly-L-lactic acid; PNIPAAm: poly(N-isopropylacrylamide).
| Material | Application | References |
|---|---|---|
| Hyaluronic acid | Cell transplantation, growth factor delivery, disease model | 134, 135, 158–162, 167, 169–172, 178, 213, 236 |
| Laminin | Cell transplantation, disease model | 170 |
| Collagen | Cell transplantation, blood–brain barrier model, disease model, drug/growth factor delivery | 149, 164, 167, 168, 178, 211, 213, 254 |
| Gelatin | Disease model, cell recruitment, growth factor delivery, cell transplantation, ex vivo cell culture | 71, 136, 160, 161, 165, 166, 234, 249 |
| Alginate | Disease model | 184 |
| Matrigel | Organoid culture, disease model, ex vivo culture | 167, 211, 238, 255, 264 |
| Fibrin | Blood–brain barrier model | 257, 258 |
| Silk | Disease model, ex vivo cell culture | 203, 205, 210 |
| Chitosan | Disease model, ex vivo cell culture | 174, 184 |
| Chondroitin sulfate | Disease model | 182 |
| Heparin/heparan sulfate | Cell transplantation, disease model | 158, 235 |
| Xycoglucan/PLLA | Growth factor delivery, cell transplantation | 173 |
| PEG | Ex vivo cell culture, disease model | 137, 138, 140, 163, 212, 235 |
| PNIPAAm-PEG | Pluripotent stem cell differentiation | 175 |
| Elastin-like proteins | Ex vivo cell culture | 141 |
| Self-assembled peptides | Ex vivo cell culture, implantation, disease model | 192–195 |
| Decellularized extracellular matrix | Ex vivo cell culture, cell recruitment, pluripotent stem cell differentiation, disease model, growth factor delivery, implantation | 196, 198, 199, 201, 202, 204, 265 |