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. Author manuscript; available in PMC: 2021 Jun 16.
Published in final edited form as: Cell Syst. 2020 Dec 16;11(6):589–607.e8. doi: 10.1016/j.cels.2020.11.006

Figure 5.

Figure 5.

Complex-level molecular mechanisms differentiating HeLa cell cycle states. The integrated STRING-based PPI network of the HeLa cell cycle dataset (Heusel et al., 2020) is depicted with proteins (nodes) and binary PPIs (edges) clustered against CORUM complexes (identifiers in brackets; STAR Methods). Different colors indicate the most significant metric-level (legend, STAR Methods). Node-size indicates effect-size and opacity indicates significance. The most prominent clusters highlight essential macromolecular assemblies. Interactive results (Cytoscape) and visualizations of separate levels are provided as Supplemental Data 1.