Table 3.
Pharmacokinetic parameters of plasma eicosapentaenoic acid + docosahexaenoic acid after supplementation with monoacylglycerol and ethyl ester.
| Pharmacokinetic parameters | Concentration EPA + DHA |
% area EPA + DHA |
||
|---|---|---|---|---|
| Mean ± SD | P value | Mean ± SD | P value | |
| Cmax | ||||
| —EE | 3.6 ± 1.9 | <0.0001 | 0.8 ± 0.4 | <0.0001 |
| —MAG | 9.7 ± 4.0 | 3.2 ± 1.2 | ||
| Concentration T = 24 h | ||||
| —EE | 1.3 ± 1.3 | 0.005 | 0.4 ± 0.4 | <0.0001 |
| —MAG | 2.5 ± 1.2 | 1.0 ± 0.3 | ||
| AUC 0–5 h | ||||
| —EE | 3.3 ± 2.5 | <0.0001 | 0.8 ± 0.6 | <0.0001 |
| —MAG | 13.0 ± 4.1 | 4.4 ± 1.6 | ||
| AUC 0–24 h | ||||
| —EE | 38.4 ± 12.4 | <0.0001 | 8.9 ± 3.2 | <0.0001 |
| —MAG | 89.6 ± 17.0 | 31.2 ± 4.2 | ||
EPA eicosapentaenoic acid, DHA docosahexaenoic acid, EE ethyl ester, MAG monoacylglycerol,
SD standard deviation, Cmax maximum concentration (mg/dL), Concentration T = 24 h concentration of FAs at 24 h post supplementation (mg/dL), AUC 0–5 h area under the curve from time 0 to 5 h post supplementation (mg/dL*h), AUC 0–24 h area under the curve from time 0 to 4 h post supplementation (mg/dL*h).