Fig. 3.

The jSR in mouse ventricular myocytes is wider and more voluminous upon HPF, compared to CFD. Top: Comparison of jSR (red arrows) in representative TT-perpendicular ET slices extracted from 3D volumes (tissue CFD and cell HPF) or 2D sections (cell CFD). Bottom: representative 3D models (green: TT; blue: jSR), segmented and quantified in ET data; ***p < 0.001; Student's t-test; n = 21–23 TT-jSR pairs/ 14–21 cells/ 3 hearts. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)