Table 1.
TT, jSR, and dyad geometry (per 100 nm of TT length) in rabbit and mouse ventricular myocytes.
| TT volume (× 106 nm3) | jSR volume (× 106 nm3) | Dyad surface (× 103 nm2) |
Dyad volume (× 103 nm3) |
|
|---|---|---|---|---|
| Rabbit | ||||
| Tissue CFD | 4.29 ± 0.46 | 0.97 ± 0.11 | 45.9 ± 4.3 | 588 ± 58 |
| Cells CFD | 4.45 ± 0.48 | 0.81 ± 0.07 | 40.1 ± 3.2 | 400 ± 28⁎⁎ |
| Cells HPF | 3.97 ± 0.44 | 2.27 ± 0.22⁎⁎⁎† | 42.3 ± 3.8 | 355 ± 30⁎⁎⁎ |
| Mouse | ||||
| Tissue CFD | 4.27 ± 0.46 | 1.2 ± 0.14 | 34.14 ± 3.4 | 270 ± 35 |
| Cells HPF | 4.09 ± 0.43 | 2.67 ± 0.17⁎⁎⁎ | 45.63 ± 4.9* | 304 ± 32 |
Dyad defined as space of jSR-TT apposition of ≤20 nm; ***p < 0.001, **p < 0.01, *p < 0.05 vs tissue CFD; †p < 0.001 vs cells CFD; one-way ANOVA with Bonferroni's post-hoc test (rabbit), Student's t-test (mouse); n = 20 TT-jSR pairs/ 16–20 cells/ 3 hearts (rabbit); n = 21–23 TT-jSR pairs/ 14–21 cells/ 3 hearts (mouse).