Fig. 1.

Alternans attenuation via ORM-10962. A) Example of APD alternans at two levels (APD25 and APD80) in control condition and following ORM-10962 exposure in muscle preparations. B) APD25 alternans at a range of pacing rates (n = 13). C) APD80 alternans at a range of pacing rates (n = 13). In B,C, paired t-test was used to compute the p-values. D) Example of reduction in CaT alternans in isolated cells via ORM-10962. E) Quantitative summary of CaT alternans (expressed as the ratio between the amplitude of the larger versus smaller CaT) without (n = 6) and with (n = 6) ORM-10962. Unpaired rank-sum test was used in E given different variance between control and ORM-10962.