Fig. 6.

ORM-10962 extends PRR. A) Experimental data from papillary muscle preparations of the shortest DI which led to formation of an action potential in the S1-S2 protocol (n = 6). B) Simulations of S1-S2 protocol under NCX block and I_CaL reduction. The leftmost point on each curve determines the PRR in the given condition. C) Simulations of S1-S2 protocol where the S1 phase was carried out using control model without any perturbation of NCX and I_CaL, with the I_CaL reduction being introduced only for the S2 beat.