TABLE III.
Mucus levels of lipid mediators in patients with AERD based on asthma severity
| Mediator | Mild asthma (n = 3) | Moderate asthma (n = 5) | Severe asthma (n = 22) | P value |
|---|---|---|---|---|
| 12,13-EpOME | 4,202 (2,426 to 20,393) | 7,500 (2,116 to 14,472) | 5,782 (2,737 to 12,313) | .90 |
| 9,10-DiHOME | 4.38 (4.00 to 23.60) | 2.70 (0.75 to 20.61) | 6.05 (3.31 to 23.36) | .74 |
| 12,13-DiHOME | 1.88 (0.01 to 4.08) | 0.89 (0.01 to 3.73) | 1.53 (0.01 to 4.32) | .91 |
| 9,10-EpOME | 315.8 (151.3 to 534.7) | 191.0 (125.3 to 570.8) | 274.9 (156.4 to 450.0) | .90 |
| 13-HODE | 9,155 (5,108 to 29,380) | 11,236 (2,724 to 19,669) | 8,461 (4,070 to 16,605) | .75 |
| 8-HETE | 16.0 (13.5 to 61.2) | 29.0 (15.5 to 48.4) | 29.3 (14.8 to 72.5) | .71 |
| 15-HETE | 3,496 (2,159 to 6,715) | 3,023 (1,465 to 9,557) | 3,594 (1,790 to 6,717) | .98 |
| 12-HETE | 376 (340 to 596) | 534 (146 to 679) | 474 (217 to 643) | .99 |
| 11,12-EET | 220.9 (164.6 to 336.6) | 274.8 (168.8 to 661.1) | 223.5 (159.4 to 337.9) | .81 |
| 14,15-EET | 642.9 (458.4 to 969.5) | 1079 (381.9 to 1,739) | 724.7 (466.6 to 959.2) | .59 |
| 20-HETE | 49,723 (37,749 to 131,101) | 42,732 (28,616 to 150,425) | 67,307 (35,685 to 116,309) | .95 |
| TxB2 | 20.9 (10.6 to 46.1) | 12.9 (6.8 to 31.1) | 16.9 (5.8 to 81.7) | .83 |
| PGD2 | 154.3 (78.1 to 161.9) | 17.9 (6.9 to 36.5) | 27.3 (15.0 to 60.2) | .02 |
| 15-Keto-PGE2 | 2.35 (2.06 to 2.81) | 0.67 (0.44 to 1.59) | 1.31 (0.78 to 1.58) | .10 |
| PGE2 | 149.8 (98.4 to 155.4) | 73.3 (41.0 to 191.1) | 90.2 (46.8 to 143.1) | .52 |
| PGF2a | 0.01 (0.01 to 46.7) | 14.0 (4.76 to 22.1) | 7.6 (0.01 to 15.2) | .71 |
| 9a,11b-PGF2a | 35.6 (34.3 to 40.4) | 13.9 (0.01 to 18.0) | 8.3 (0.01 to 20.2) | .03 |
| LTB4 | 0.01 (0.01 to 81.2) | 3.9 (0.01 to 93.6) | 0.01 (−0.01 to 10.7) | .54 |
| LTC4 | 125.7 (32.0 to 470.6) | 38.7 (13.0 to 120.7) | 22.9 (6.23 to 64.77) | .10 |
| LTD4 | 0.01 (0.01 to 0.01) | 0.01 (0.01 to 2.54) | 2.06 (0.01 to 4.04) | .05 |
| LTE4 | 1.29 (0.84 to 1.87) | 3.73 (1.82 to 17.3) | 5.34 (3.67 to 12.75) | .15 |
| Total CysLTs | 126.6 (33.3 to 472.2) | 43.9 (32.1 to 122.5) | 36.6 (17.7 to 74.1) | .16 |
Median levels of lipid mediators in patients with AERD and mild, moderate, or severe asthma are shown. All mediator levels are presented as ng/mL. Significant differences between groups were identified by the Kruskal-Wallis test followed by Dunn’s test for multiple comparisons. Data are presented as medians with interquartile range. Boldface text indicates P value of less than .05.