Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 9;11:7834. doi: 10.1038/s41598-021-87324-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

EVR primarily causes injury to the white matter. (a) Immunohistochemistry for myelin basic protein (MBP) in EVR dogs #1–3 versus OR. Cross-sections were at L5 level. (b), (c) Box and whisker plots showing MBP levels assessed by IHC on cross-sections of the SC throughout the L1–L5 region (b) or the T13–L3 region (c). C, control; OR, open repair; E1 and E3, EVR dog#1 and dog#3, respectively. Horizontal bars show the lower (first quartile), the median (second quartile) and the upper (third quartile) quartiles from bottom to top. The cross represents the mean value. (d) Box and whisker plots showing the dispersion of the mean levels of MBP expression in the cervical (C1, C3, C5 and C7), thoracic (T3, T5, T7, T9, T11 and T13) and lumbar (L1, L3, L5 and L7) regions of the SC of EVR dogs #1–3. (e) Reduced MBP level (arrowheads) in the cervical SC of EVR dog#2. (f) IHC for neurofilament heavy polypeptide in EVR dog#3 versus OR. Cross sections were at L5 level. (g) Neuronal density at the L1, L3, L5 and L7 levels in a control dog, an OR dog, and EVR dog#1 (E1), dog#2 (E2) and dog#3 (E3) was quantified by assessing the number of neurons per 10X field (given as mean ± standard deviation) as determined by pyruvate dehydrogenase testing. Scale bars are in µm.