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. 2021 Apr 9;12(4):385. doi: 10.1038/s41419-021-03671-2

Fig. 4. HuR deletion resulted in defective autophagy.

Fig. 4

A Transmission electron microscopy of autophagosomes (black arrow) in VSMCs infected with ad-HuR or ad-LacZ. Scale bar = 5000 nm (left), 1000 nm (middle), 500 nm (right). B–D fluorescence photomicrographs (B) and quantification (C, D) of GFP-mRFP-LC3II puncta in VSMCs infected with ad-HuR or ad-LacZ (n = 26). Scale bar = 10 μm. E–G Fluorescence photomicrographs (E) and quantification (F, G) of GFP-mRFP-LC3II puncta in VSMCs transfected with control or HuR siRNA (n = 26). Scale bar = 10 μm. Yellow puncta denotes autophagosome. Red puncta denotes autolysosome.