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. 2021 Apr 9;11:7838. doi: 10.1038/s41598-021-87476-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AAV9CMVCre mediated Rac1 KO does not impair recovery after SCI. (A, B) Biomechanical impact data provided by the Infinite Horizon impactor demonstrates that SCI Rac1−/− and SCI control groups received consistent injuries. (C) Blinded observers performed BMS testing at baseline, and weekly following SCI (Wk1-Wk4). Both SCI Rac1−/− and SCI control groups recovery equally over a 4-week period. (D) Representative video-still image of paw prints used for stepping pattern analysis acquired and analysis using the CatWalkXT (Noldus Information Technology). (E) Intensity plot of the left hind paw (virally injected side) acquired using the CatWalkXT (Noldus Information Technology) from an SCI animal four weeks post injury. (F) Four weeks after SCI, both SCI Rac1−/− and SCI control groups have a gait pattern (regularity index) similar to baseline testing. (G) Swing speed of the right (RH) and left (LH) hind limbs of SCI Rac1−/− and SCI group. Post SCI and viral injection there was no difference between hindlimb swing speed and compared to baseline. (* = p < 0.05). Graphs are mean ± SEM.