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. 2021 Apr 9;11:7838. doi: 10.1038/s41598-021-87476-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intramuscular injection of AAV9CMVCre leads to expression of tdTomato in ventral spinal cord motor neurons. (A) ChAT positive motor neurons within lamina IX of the spinal cord. (B) AAV9CMVCre transfected motor neurons expressing tdTomato. (C) Merged image of (A) and (B) shows colocalization of ChAT positive neurons and tdTomato expression (arrow shows inset *). (D) The percentage of ChAT labelled motor neuron expressing tdTomato in the ventral horn of the spinal cord. AAV9CMVCre intramuscular injection tranfects 51.2% of ChAT-positive neurons in lamina IX on the ipsilateral injected side (Ipsi-). On the contralateral side (Contra-) there was no co-labelling between ChAT motor neurons and tdTomato expression. Data shown as scatterplot with mean. Scale bar in (A) = 50 µm and applies to images in (B) and (C).