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. 2021 Apr 9;11:7838. doi: 10.1038/s41598-021-87476-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Conditional Rac1 KO in alpha-motor neurons did not alter microglia or astrocyte reactivity in the ventral horn. (A, B) IBA1 immunolabelling for microglia in the ventral horn of the spinal cord in SCI animals with (A) Rac1 or (B) Rac1 KO in alpha motor neurons. (C) No difference in the percent area labelled for IBA1 between SCI and SCI Rac1−/− groups. (D, E) Image of GFAP immunolabelling for astrocytes in the ventral horn of the spinal cord from animals with (D) Rac1 or (E) Rac1 KO in alpha motor neurons. (F) There was no difference in the percent area labelled for GFAP between SCI and SCI Rac1−/− groups. Graphs are Mean ± SEM; Scale bar in (A) and (D) = 50 µm and applies to images in (B), and (E).