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. 2021 Apr 9;12:2135. doi: 10.1038/s41467-021-22430-7

Fig. 2. Inhibition of distinct NAc glutamatergic inputs has opposing effects on high fat intake.

Fig. 2

a Schematic of experimental setup (left); experimental timeline (right). b Schematic of viral injection and ferrule implant for aPVT input inhibition (left); representative images of NpHR infection in the aPVT and NAc (right). c, d Quantification of high fat intake during acquisition (c: F3,66 = 3.71, P = 0.01, n = 10,14 mice/group) and expression period (d: F2,44 = 8.04, P = 0.001, n = 14,10 mice/group) in eYFP control (black) and NpHR expressing (green) mice. Green bars signify green light stimulation. e Schematic of viral injection and ferrule implant for PFC input inhibition (left); representative images of NpHR infection in the PFC and NAc (right). f, g Quantification of high fat intake during acquisition (f: F3,99 = 3.23, P = 0.03, n = 19,16 mice/group) and expression period (g: F2,62 = 2.95, P = 0.047, n = 16,17 mice/group). Data are ±s.e.m. *P < 0.05, two-way ANOVA with Sidak’s multiple comparison post hoc test. Source data are provided as a Source Data file.