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. 2021 Apr 9;12:2135. doi: 10.1038/s41467-021-22430-7

Fig. 5. Chronic high fat intake modifies MSN synaptic strength in an input- and cell type-specific manner.

Fig. 5

a Schematic of experimental setup (top); experimental timeline (bottom). b (top) Daily intake of standard chow (SC) or high fat (HF) for mice expressing ChR2 in the PFC or aPVT; (bottom) Quantification of cumulative limited-access intake for PFC (n = 6/group) and aPVT mice (n = 9/group). c, d Representative traces of mice exposed to SC versus HF (left). Quantification of AMPAR/NMDAR ratio in D1 MSNs for (c) aPVT (t = 2.77, P = 0.01, n = 9, 14 cells/group, red) and (d) PFC (n = 13, 7 cells/group, blue) inputs. e, f Representative traces of mice exposed to SC versus HF (left). Quantification of AMPAR/NMDAR ratio in D2 MSNs for (e) aPVT (n = 9 cells/group, red) and (f) PFC (t = 2.37, P = 0.03, n = 7, 10 cells/group, blue) inputs. Data are ±s.e.m. *P < 0.05, Student’s t test two-tailed. Source data are provided as a Source Data file.