Table 1.
H &E and TRAP stained bone sections were used for analyses in BioQuant-Osteoimage analysis software
| Parameters | 36 + 14 weeks scrambled | 36 + weeks inhibitory |
|---|---|---|
| Static | ||
| Cancellous bone/% | 10.65 ± 3.3 | 14.36 ± 2.86 |
| Trabecular number/mm−1 | 1.06 ± 0.23 | 2.25 ± 0.46* |
| Trabecular thickness/µm | 7.8 ± 1.6 | 12.43 ± 2.3** |
| Trabecular separation/µm | 420.8 ± 35.92 | 302.6 ± 15.9** |
| Osteoclast number | 29.93 ± 10.87 | 25.5 ± 8.58 |
| Osteoblast number | 179 ± 35.47 | 214 ± 42.81 |
| Cortical width/µm | 158 ± 7.3 | 165.8 ± 6.83 |
| Dynamic | ||
| MAR/(μm·d−1) | 0.38 ± 0.05 | 0.42 ± 0.09 |
| Bone formation rate/(μm2·μm−1 per day) | 0.30 ± 0.08 | 0.29 ± 0.03 |
Data shown are mean ± SEM of nine mice from one experiment (n = 9 per group)
*P < 0.05 and **P < 0.01 vs. scrambled peptide injected mice. The standard Student’s t test was used to assess P values. The results represent one of the three experiments performed