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. 2021 Apr 9;7:40. doi: 10.1038/s41523-021-00248-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Western blot analysis showing downregulation of the PI3K pathway activity as indicated by decreased expression of PI3K pathway downstream components in HCC1143 following siTGFBR2 treatment (96 h) relative to siControl treatment. p-SMAD2 downregulation is used as a positive control for TGFBR2 protein depletion. b Similar results were observed in HCC1954 cells. c Lentiviral overexpression of TGFBR2 restores pAkt levels in siSOX4 (96 h) treated HCC1143 cells. d Consistent results were observed in HCC1954 cells.