Table 2.
Summary statistics for the 65 SNPs associated with cognitive function at a suggestive significance level (P < 1×10−5). SNP positions and distance to nearest gene are based on the GRCh37/hg19 genome build. Nearest gene refers to nearest RefSeq gene. SNPs identified by FUMA as independent SNPs are highlighted in bold. Independent SNPs in LD with candidate SNPs found to replicate (P < 0.05) are marked with *.
| SNP | Chr | Position | Locus | Ma | MAF | Beta | P | Nearest Gene | Distance |
|---|---|---|---|---|---|---|---|---|---|
| rs17265690 | 5 | 13816888 | 5p15.2 | G | 0.0138 | 13.63 | 1.22E-07 | DNAH5 | 0 (intron) |
| rs114012368 | 5 | 13845391 | 5p15.2 | G | 0.0153 | 11.14 | 1.70E-07 | DNAH5 | 0 (intron) |
| rs187473706* | 10 | 58207108 | 10q21.1 | A | 0.1277 | −4.579 | 2.73E-07 | ZWINT | 86074 |
| rs4405235 | 10 | 58103101 | 10q21.1 | G | 0.1313 | −4.577 | 2.74E-07 | ZWINT | 14098 |
| rs11005326 | 10 | 58117124 | 10q21.1 | G | 0.1313 | −4.577 | 2.74E-07 | ZWINT | 75 |
| rs11005338 | 10 | 58125900 | 10q21.1 | G | 0.1313 | −4.577 | 2.74E-07 | ZWINT | 4866 |
| rs11005320 | 10 | 58096959 | 10q21.1 | C | 0.1319 | −4.564 | 3.32E-07 | ZWINT | 20240 |
| rs28502528 | 3 | 7210895 | 3p26.1 | G | 0.3073 | 3.391 | 3.74E-07 | GRM7 | 0 (intron) |
| rs58796432 | 10 | 58208170 | 10q21.1 | T | 0.1304 | −4.493 | 4.30E-07 | ZWINT | 87136 |
| rs11005358 | 10 | 58209898 | 10q21.1 | A | 0.1304 | −4.493 | 4.30E-07 | ZWINT | 88864 |
| rs74137635 | 10 | 58210671 | 10q21.1 | C | 0.1304 | −4.493 | 4.30E-07 | ZWINT | 89583 |
| rs12266849 | 10 | 58218034 | 10q21.1 | G | 0.1304 | −4.493 | 4.30E-07 | ZWINT | 97000 |
| rs12257459 | 10 | 58208672 | 10q21.1 | G | 0.1303 | −4.487 | 4.94E-07 | ZWINT | 87638 |
| rs2087837 | 10 | 58222830 | 10q21.1 | A | 0.1303 | −4.487 | 4.94E-07 | ZWINT | 101796 |
| rs11005363 | 10 | 58237680 | 10q21.1 | C | 0.1302 | −4.487 | 4.94E-07 | ZWINT | 116646 |
| rs58386275 | 10 | 58241470 | 10q21.1 | C | 0.1301 | −4.487 | 4.94E-07 | ZWINT | 120436 |
| rs11005366 | 10 | 58242596 | 10q21.1 | T | 0.1301 | −4.487 | 4.94E-07 | ZWINT | 121562 |
| rs4935645 | 10 | 58021087 | 10q21.1 | C | 0.1391 | −4.405 | 5.04E-07 | ZWINT | 96112 |
| rs2393046 | 10 | 58023980 | 10q21.1 | T | 0.1388 | −4.405 | 5.04E-07 | ZWINT | 93219 |
| rs74137642 | 10 | 58243119 | 10q21.1 | G | 0.1306 | −4.427 | 6.16E-07 | ZWINT | 122085 |
| rs7091142 | 10 | 58244433 | 10q21.1 | T | 0.1306 | −4.427 | 6.16E-07 | ZWINT | 123399 |
| rs141232317 | 10 | 58206613 | 10q21.1 | T | 0.1208 | −4.453 | 8.32E-07 | ZWINT | 85579 |
| rs2263916 | 10 | 58161893 | 10q21.1 | G | 0.1317 | −4.386 | 9.30E-07 | ZWINT | 40859 |
| rs10763369 | 10 | 58175630 | 10q21.1 | A | 0.1315 | −4.386 | 9.30E-07 | ZWINT | 54596 |
| rs10733958 | 10 | 58179399 | 10q21.1 | G | 0.1315 | −4.386 | 9.30E-07 | ZWINT | 58365 |
| rs1516302 | 3 | 7208953 | 3p26.1 | A | 0.3005 | 3.199 | 1.24E-06 | GRM7 | 0 (intron) |
| rs11005287 | 10 | 58024579 | 10q21.1 | A | 0.1378 | −4.246 | 1.24E-06 | ZWINT | 92620 |
| rs114240283 | 5 | 13799563 | 5p15.2 | A | 0.0148 | 11.63 | 1.33E-06 | DNAH5 | 0 (intron) |
| rs12264147 | 10 | 58025087 | 10q21.1 | T | 0.1387 | −4.187 | 1.62E-06 | ZWINT | 92112 |
| rs2393054 | 10 | 58056974 | 10q21.1 | C | 0.1395 | −4.167 | 1.66E-06 | ZWINT | 60225 |
| rs12257337 | 10 | 58062019 | 10q21.1 | T | 0.1390 | −4.146 | 1.86E-06 | ZWINT | 55180 |
| rs7099218 | 10 | 58067127 | 10q21.1 | C | 0.1390 | −4.146 | 1.86E-06 | ZWINT | 50072 |
| rs12255620 | 10 | 58076723 | 10q21.1 | G | 0.1387 | −4.146 | 1.86E-06 | ZWINT | 40476 |
| rs73280169 | 10 | 58077515 | 10q21.1 | T | 0.1388 | −4.146 | 1.86E-06 | ZWINT | 39684 |
| rs114740310 | 5 | 13870802 | 5p15.2 | T | 0.0144 | 11.17 | 1.92E-06 | DNAH5 | 0 (intron) |
| rs114933297 | 5 | 13874625 | 5p15.2 | T | 0.0145 | 11.17 | 1.92E-06 | DNAH5 | 0 (intron) |
| rs595286 | 18 | 60280097 | 18q21.33 | G | 0.4679 | −2.964 | 2.10E-06 | ZCCHC2 | 26121 |
| rs9392881 | 6 | 791124 | 6p25.3 | G | 0.1214 | −4.441 | 2.42E-06 | LOC101927691 | 77374 |
| rs9392150 | 6 | 791318 | 6p25.3 | A | 0.1211 | −4.421 | 2.46E-06 | LOC101927691 | 77180 |
| rs62384998 | 6 | 791566 | 6p25.3 | C | 0.1212 | −4.426 | 2.47E-06 | LOC101927691 | 76932 |
| rs7763687 | 6 | 791850 | 6p25.3 | T | 0.1212 | −4.426 | 2.47E-06 | LOC101927691 | 76648 |
| rs306213 | 18 | 60291954 | 18q21.33 | A | 0.3434 | −3.146 | 2.67E-06 | ZCCHC2 | 37978 |
| rs62385000 | 6 | 792759 | 6p25.3 | A | 0.1214 | −4.432 | 2.79E-06 | LOC101927691 | 75739 |
| rs11005317 | 10 | 58088163 | 10q21.1 | G | 0.1407 | −4.021 | 2.90E-06 | ZWINT | 29036 |
| rs3750796 | 10 | 58088534 | 10q21.1 | G | 0.1407 | −4.021 | 2.90E-06 | ZWINT | 28665 |
| rs7094892 | 10 | 58088575 | 10q21.1 | T | 0.1407 | −4.021 | 2.90E-06 | ZWINT | 28624 |
| rs2393065 | 10 | 58089291 | 10q21.1 | C | 0.1407 | −4.021 | 2.90E-06 | ZWINT | 27908 |
| rs9971280 | 10 | 58090264 | 10q21.1 | C | 0.1406 | −4.021 | 2.90E-06 | ZWINT | 26935 |
| rs59704796 | 10 | 58090554 | 10q21.1 | C | 0.1406 | −4.021 | 2.90E-06 | ZWINT | 26645 |
| rs637216 | 18 | 60282910 | 18q21.33 | G | 0.4677 | −2.919 | 3.18E-06 | ZCCHC2 | 28934 |
| rs3750795 | 10 | 58088644 | 10q21.1 | G | 0.1403 | −4.012 | 3.30E-06 | ZWINT | 28555 |
| rs72773940 | 10 | 11148581 | 10p14 | T | 0.0287 | −8.131 | 3.58E-06 | CELF2 | 0 (intron) |
| rs117481327 | 10 | 11154826 | 10p14 | G | 0.0293 | −8.121 | 3.61E-06 | CELF2 | 0 (intron) |
| rs2016129* | 10 | 29288295 | 10p12.1 | T | 0.0682 | 5.091 | 3.84E-06 | C10orf126 | 117468 |
| rs114594327 | 4 | 91942029 | 4q22.1 | T | 0.0268 | 7.955 | 5.09E-06 | CCSER1 | 0 (intron) |
| rs74897566 | 3 | 5083637 | 3p26.1 | C | 0.0196 | 10.88 | 6.29E-06 | BHLHE40 | 56771 |
| rs306216 | 18 | 60295543 | 18q21.33 | G | 0.3009 | −3.131 | 6.92E-06 | ZCCHC2 | 41567 |
| rs1556397* | 10 | 24851710 | 10p12.1 | A | 0.3311 | −2.923 | 7.86E-06 | KIAA1217 | 14938 |
| rs141363063 | 9 | 116670492 | 9q32 | T | 0.0110 | 11.55 | 8.44E-06 | ZNF618 | 0 (intron) |
| rs148488001 | 9 | 116691092 | 9q32 | G | 0.0110 | 11.55 | 8.44E-06 | ZNF618 | 0 (intron) |
| rs192345176 | 9 | 116700201 | 9q32 | G | 0.0109 | 11.55 | 8.44E-06 | ZNF618 | 0 (intron) |
| rs138203943 | 9 | 116704225 | 9q32 | A | 0.0109 | 11.55 | 8.44E-06 | ZNF618 | 0 (intron) |
| rs56139919* | 6 | 155914380 | 6q25.3 | A | 0.0207 | 8.531 | 8.72E-06 | LOC105378068 | 67228 |
| rs489500 | 1 | 65525901 | 1p31.3 | G | 0.0139 | 9.476 | 8.94E-06 | JAK1 | 0 (intron) |
| rs11007349 | 10 | 29287378 | 10p12.1 | T | 0.0674 | 5.102 | 9.50E-06 | C10orf126 | 116551 |