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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Mech Ageing Dev. 2021 Jan 30;195:111443. doi: 10.1016/j.mad.2021.111443

Fig. 2.

Fig. 2.

Pathway analysis reveals that PKA pathway is activated by aging and suppressed by CR. (A) Output of kinase-substrate enrichment analysis (KSEA). Red and blue bars indicate significant differences (p < 0.05). (B) Depiction of kinase-substrate links produced by analysis in (A). (C) Volcano plots for Old-AL vs. Young-AL, and Old-CR vs. Old-AL comparisons. Data points in maroon indicate known PKA targets identified by KSEA.