Table 1.

Statistical output for the analysis depicted in Figure 2A. mS refers to the mean log₂FC for all the kinase’s substrates; Enrichment is the background-adjusted value of the kinase’s mS; m is the total number of detected substrates for each kinase in the given dataset; z.score is the normalized weighted score for each kinase; and p.value is the statistical assessment of the z.score.

Old-AL vs. Young-AL
Kinase	log2FC	mS	Enrichment	m	z.score	p.value
Akt1	0.772913	0.772913	4.864807356	5	2.969199	0.001493
Mapk14	0.613815	0.613815	3.86342894	5	2.199874	0.013908
Prkaca	0.404018	0.404018	2.542937765	10	1.676389	0.046831
Prkaa1	0.436001	0.436001	2.744246924	6	1.467946	0.071059
Mapk1	0.376791	0.376791	2.371567959	6	1.154302	0.124188
Mtor	0.351794	0.351794	2.214232646	6	1.02189	0.153417
Prkca	0.177378	0.177378	1.116439194	6	0.097994	0.460968
Old-CR vs. Old-AL
Kinase	log2FC	mS	Enrichment	m	z.score	p.value
Akt1	0.248203	0.248203	19.64769106	5	1.675636	0.046905
Prkaa1	0.008721	0.008721	0.690349965	6	0.150271	0.440275
Mtor	0.002931	0.002931	0.232047638	6	0.109528	0.456392
Mapk14	−0.22758	−0.22758	−18.0148868	5	−1.38082	0.083667
Mapk1	−0.25221	−0.25221	−19.9647463	6	−1.68595	0.045902
Prkca	−0.30694	−0.30694	−24.2971956	6	−2.07111	0.019174
Prkaca	−0.34876	−0.34876	−27.6075815	10	−3.05372	0.00113