Figure 1. Liver-specific loss of SELENOP does not modify inflammatory tumorigenesis.

(A) Cohorts of Selenop^WT and Selenop^ΔHep mice were placed on an AOM/DSS inflammatory colitis protocol consisting of 3 cycles of 4-day DSS treatment followed by 16 days of recovery. (B) Total SELENOP protein was assessed from plasma of Selenop^WT and Selenop^ΔHep mice (n=10/genotype). (C) Total selenium (n=6/genotype) and (D) GPx activity (n=15 Selenop^WT and n=8 Selenop^ΔHep) measured from non-tumor colonic tissue. (E) Colon length, (F) gross tumor number, and (G) gross tumor size (n=16 Selenop^WT and 17 Selenop^ΔHep). Tumor size was measured with calipers and numbers represent tumor length × tumor width averaged per mouse. *P<0.05, ****P<0.0001, Student’s t test.