Table 3.

Associations between Rest-Activity Rhythms and Cardiometabolic Biomarkers after adjustment for BMI

Rest-Activity Rhythm Parameter	Cardiometabolic Biomarker	Model 4
		β (95% CI)
Interdaily Stability	Systolic BP, mmHg	−0.67 (−2.63, 1.30)
	Diastolic BP, mmHg	−0.25 (−2.17, 1.66)
	Total-C, mg/dL	−9.92 (−17.05, −2.79)†
	LDL-C, mg/dL	−6.51 (−12.74, −0.27)*
	HDL-C, mg/dL	−2.10 (−5.78, 1.57)
	Non-HDL-C, mg/dL	−7.82 (−14.46, −1.17)*
	Triglycerides, mg/dL	−10.10 (−18.41, −1.79)*
	Glucose, mg/dL	−0.51 (−2.42, 1.39)
	CRP, mg/L	−0.21 (−0.45, 0.04)
Intradaily Variability	Systolic BP, mmHg	−0.11 (−2.10, 1.88)
	Diastolic BP, mmHg	−0.03 (−1.96, 1.90)
	Total-C, mg/dL	7.75 (−0.94, 16.39)
	LDL-C, mg/dL	4.00 (−2.50, 10.50)
	HDL-C, mg/dL	2.02 (−1.71, 5.75)
	Non-HDL-C, mg/dL	5.15 (−1.81, 12.11)
	Triglycerides, mg/dL	7.18 (−0.34, 14.69)
	Glucose, mg/dL	0.43 (−1.51, 2.36)
	CRP, mg/L	0.30 (0.06, 0.55)*
Relative Amplitude	Systolic BP, mmHg	−1.19 (−3.17, 0.81)
	Diastolic BP, mmHg	−0.36 (−2.33, −1.61)
	Total-C, mg/dL	−6.28 (−15.11, 2.55)
	LDL-C, mg/dL	−5.39 (−11.87, 1.09)
	HDL-C, mg/dL	0.43 (−3.38, 4.24)
	Non-HDL-C, mg/dL	−6.17 (−13.13, 0.78)
	Triglycerides, mg/dL	−5.74 (−13.43, 1.95)
	Glucose, mg/dL	0.20 (−1.75, 2.15)
	CRP, mg/L	−0.09 (−0.33, 0.14)
Autocorrelation at 24h	Systolic BP, mmHg	−0.53 (−2.48, 1.41)
	Diastolic BP, mmHg	−0.72 (−2.61, 1.16)
	Total-C, mg/dL	−8.24 (−15.44, −1.04)*
	LDL-C, mg/dL	−5.47 (−11.70, 0.76)
	HDL-C, mg/dL	−1.68 (−5.33, 1.96)
	Non-HDL-C, mg/dL	−6.56 (−13.22, 0.10)
	Triglycerides, mg/dL	−7.62 (−16.03, 0.78)
	Glucose, mg/dL	−0.19 (−2.07, 1.70)
	CRP, mg/L	−0.24 (−0.48, −0.01)*

Results are presented as unstandardized β values and 95% confidence intervals (CI) for every 1-SD increase in each rest-activity rhythm parameter. Model 4 also adjusts for sex.

^*p≤0.05

^†p≤0.01. BP, blood pressure; C, cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; CRP, C-reactive protein