Table 3.
Subgroup analysis obtained from the proposed CNN of DWI connectome data. The prediction performance metrics including MAE, SDAE and P(MAE≤15) were assessed at different subgroups via the repeated hold-out validation procedure. None of below subgroup comparisons showed a significant group effect on the performance metrics of expressive and receptive language scores (p-value > 0.08*).
| Subgroup | Expressive score | Receptive score | ||||
|---|---|---|---|---|---|---|
| MAE | SDAE | P(MAE≤15) | MAE | SDAE | P(MAE≤15) | |
| Onset age ≤ 5 y.o (n=21) | 7.16±5.03 | 3.99±2.73 | 0.93±0.16 | 7.00±6.88 | 4.14±3.36 | 0.90±0.24 |
| Onset age > 5 y.o (n=16) | 8.58±7.93 | 4.96±3.99 | 0.86±0.24 | 7.93±7.57 | 4.81±5.06 | 0.85±0.26 |
| Weekly or monthly seizure frequency (n=25) | 7.87±4.95 | 4.37±2.83 | 0.90±0.17 | 8.13±8.04 | 4.81±4.77 | 0.87±0.26 |
| Daily seizure frequency (n=12) | 7.56±8.94 | 4.50±4.23 | 0.90±0.25 | 5.89±4.48 | 3.64±2.23 | 0.90±0.22 |
| Duration ≤ 5 year (n=14) | 8.17±8.37 | 4.87±4.22 | 0.87±0.25 | 8.33±7.98 | 5.13±5.31 | 0.83±0.27 |
| Duration > 5 year (n=23) | 7.52±5.01 | 4.13±2.68 | 0.91±0.16 | 6.84±6.62 | 3.99±3.26 | 0.90±0.22 |
| Number of AED ≤ 2 (n=25) | 6.50±3.35 | 4.00±2.11 | 0.92±0.13 | 7.22±6.82 | 4.40±4.40 | 0.89±0.23 |
| Number of AED > 2 (n=12) | 10.41±9.88 | 5.25±2.21 | 0.84±0.29 | 7.79±7.95 | 4.50±3.65 | 0.85±0.28 |
| Right handedness (n=31) | 7.96±6.75 | 4.53±3.53 | 0.90±0.21 | 7.77±7.65 | 4.69±4.44 | 0.86±0.27 |
| Left handedness (n=6) | 6.76±4.22 | 3.78±1.99 | 0.90±0.15 | 5.50±2.55 | 3.10± 1.35 | 0.98±0.03 |
| Without dysplasia (n=28) | 8.56±7.21 | 4.87±3.79 | 0.87±0.21 | 7.90±7.67 | 4.70±4.54 | 0.85±0.25* |
| With dysplasia (n=9) | 6.09±3.47 | 3.54±1.37 | 0.95±0.13 | 4.66±1.19 | 2.99±0.63 | 0.99±0.00* |