TABLE 3.
Significant volumetric differences according to disability progression and optimal cutoffs
| Variable | Disability progression Mean (95% CI) | No disability progression Mean (95% CI) | p | Cutoff | ||||
|---|---|---|---|---|---|---|---|---|
| Value | Accuracy | Sensitivity | Specificity | AUC | ||||
| Baseline volume (mm3) | ||||||||
| WM adjacent to right amygdala | 896.3 (842.7–1037.5) | 1,103.6 (1,116.9–1194.1) | .013 | 1,364.3 | 0.364 | 0.833 | 0.188 | 0.747 |
| WM adjacent to left cuneus | 3,245.0 (2,843.8–3513.0) | 4,367.4 (4,053.2–4302.0) | .018 | 2,740.0 | 0.727 | 0.333 | 0.875 | 0.734 |
| GM left cuneus | 4,888.1 (4,733.0–5579.4) | 5,868.9 (5,475.5–5853.6) | .005 | 5,414.8 | 0.682 | 0.750 | 0.656 | 0.779 |
| GM right parahippocampal gyrus | 6,797.9 (6,579.3–7215.1) | 7,468.5 (7,457.5–7824.7) | .012 | 7,926.6 | 0.419 | 0.833 | 0.258 | 0.750 |
| GM right insula | 9,321.1 (9,480.4–9673.8) | 10,270.3 (10,240.2–10390.1) | .022 | 11,009.1 | 0.372 | 0.909 | 0.188 | 0.733 |
| GM left superior frontal gyrus | 13,781.0 (13,923.6–14717.3) | 12,532.4 (12,250.5–12725.8) | .023 | 14,623.1 | 0.682 | 0.250 | 0.844 | 0.724 |
| GM declive (V7) | 1,073.0 (952.5–1189.1) | 1,261.9 (1,210.0–1348.8) | .034 | 1,143.7 | 0.636 | 0.583 | 0.656 | 0.711 |
| GM right inferior temporal gyrus | 14,595.4 (14,291.9–15619.2) | 15,827.6 (15,773.6–16413.2) | .035 | 15,705.3 | 0.636 | 0.833 | 0.563 | 0.708 |
| GM right superior temporal gyrus (pole) | 5,246.1 (4,838.0–5369.0) | 5,644.3 (5,558.5–5685.2) | .036 | 5,213.0 | 0.738 | 0.500 | 0.833 | 0.711 |
| GM right calcarine sulcus | 6,045.1 (5,828.6–6306.2) | 6,620.6 (6,558.2–6830.8) | .043 | 5,933.0 | 0.705 | 0.500 | 0.781 | 0.701 |
| 12‐month volume (mm3) | ||||||||
| WM left superior longitudinal fasciculus (temporal part) | 9.6 (9.7–10.3) | 5.3 (3.8–6.3) | .014 | 6.2 | 0.628 | 0.750 | 0.581 | 0.743 |
| WM adjacent to right globus pallidus | 1,006.6 (985.9–1111.5) | 1,214.9 (1,196.3–1278.2) | .020 | 1,205.5 | 0.595 | 0.818 | 0.516 | 0.739 |
| WM adjacent to left middle temporal gyrus | 9,584.6 (9,038.5–10033.4) | 11,058.5 (10,101.8–11276.7) | .028 | 8,551.9 | 0.636 | 0.167 | 0.813 | 0.716 |
| WM adjacent to left cuneus | 3,556.0 (3,308.1–4037.0) | 4,326.8 (4,055.1–4555.0) | .036 | 3,103.5 | 0.698 | 0.417 | 0.806 | 0.710 |
| WM adjacent to left lingual gyrus | 4,473.1 (4,241.1–4911.8) | 5,394.8 (5,073.6–5246.9) | .049 | 5,267.1 | 0.636 | 0.833 | 0.563 | 0.695 |
| GM left cuneus | 5,200.2 (5,012.9–5572.0) | 5,971.1 (5,727.6–6095.6) | .017 | 6,140.8 | 0.568 | 0.833 | 0.469 | 0.734 |
| GM left insula | 9,644.3 (9,508.9–10104.6) | 10,478.2 (10,119.9–10682.5) | .035 | 10,905.0 | 0.455 | 0.917 | 0.281 | 0.708 |
| GM left cingulate gyrus | 7,403.9 (7,670.2–8199.0) | 8,380.3 (7,942.1–8272.5) | .040 | 7,758.4 | 0.727 | 0.750 | 0.719 | 0.703 |
Abbreviations: AUC, area under the curve; CI, confidence interval; GM, gray matter; WM, white matter.