TABLE 4.

Significant normalized volumetric differences according to disability progression and optimal cutoffs

Variable	Disability progression Mean (95% CI)	No disability progression Mean (95% CI)	P	Cutoff
				Value	Accuracy	Sensitivity	Specificity	AUC
Baseline volume (mm3)
WM adjacent to right amygdala	0.1 (0.0–0.1)	0.1 (0.1–0.1)	.001	0.1	0.738	0.727	0.742	0.824
WM adjacent to left cuneus	0.2 (0.2–0.3)	0.3 (0.3–0.3)	.023	0.3	0.682	0.750	0.656	0.724
GM left cuneus	0.3 (0.3–0.4)	0.4 (0.4–0.4)	.021	0.4	0.705	0.667	0.719	0.727
GM right parahippocampal gyrus	0.5 (0.4–0.5)	0.5 (0.5–0.5)	.006	0.5	0.780	0.727	0.800	0.776
GM right insula	0.7 (0.6–0.7)	0.7 (0.7–0.8)	.034	0.7	0.674	0.545	0.719	0.716
GM left superior frontal gyrus	1.0 (0.9–1.0)	0.9 (0.8–0.9)	.020	0.9	0.651	0.727	0.625	0.736
GM right inferior temporal gyrus	1.0 (1.0–1.1)	1.1 (1.1–1.2)	.049	1.1	0.568	0.500	0.594	0.695
GM right culmen (C4−5)	0.5 (0.4–0.5)	0.4 (0.4–0.4)	.033	0.5	0.682	0.667	0.688	0.711
12‐month volume (mm3)
WM left cingulum (cingulate gyrus)	0.0 (0.0–0.1)	0.1 (0.1–0.1)	.049	0.1	0.614	0.750	0.563	0.695
WM adjacent to right putamen	0.3 (0.2–0.3)	0.3 (0.3–0.3)	.043	0.3	0.705	0.667	0.719	0.701
GM left cuneus	0.4 (0.3–0.4)	0.4 (0.4–0.4)	.014	0.4	0.705	0.667	0.719	0.740
GM left posterior cingulate gyrus	0.2 (0.1–0.2)	0.1 (0.1–0.2)	.041	0.2	0.738	0.545	0.806	0.710
GM triangular part of right inferior frontal gyrus	0.5 (0.4–0.5)	0.4 (0.4–0.5)	.037	0.4	0.581	0.667	0.548	0.707
GM left hippocampus	0.4 (0.3–0.4)	0.4 (0.4–0.4)	.009	0.4	0.791	0.636	0.844	0.764
GM right culmen (C4−5)	0.5 (0.4–0.5)	0.4 (0.4–0.5)	.025	0.5	0.659	0.583	0.688	0.721

Abbreviations: AUC, area under the curve; CI, confidence interval; GM, gray matter; WM, white matter.