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. 2021 Apr 9;41(4):BSR20201738. doi: 10.1042/BSR20201738

Figure 4. Overexpression of HMGB1 attenuates the myocardial protective effect of GAS5 knockdown on septic mice.

Figure 4

(A) Western blot was used to detect the effect of overexpression of HMGB1 on the expression of HMGB1 in septic mice. (B) HE staining was used to observe the effect of HMGB1 overexpression on myocardial pathological damage in septic mice. (C) The effects of HMGB1 overexpression on the levels of TNF-α, IL-6 and IL-1β in septic mice were detected by ELISA. (D) Nitrite/nitrate kit was used to detect the content of NO in myocardium of septic mice after knockdown of GAS5 and HMGB1 overexpression. The sample size of all groups was n=6, and the results were expressed by means ± SD. The differences between groups were analyzed by independent sample t test, **P<0.01 compared with LV-GAS5 + oe-NC group.