(A) Significant differences in body weight between the DN (db/db DN mice group, n=5) and DN+NaB (db/db DN mice treated with NaB group, n=5) groups. (B) There are no significant differences between the DN and DN+NaB groups in terms of fasting blood glucose, *P<0.05, **P<0.01. (C) Significant differences exist between the DN and DN+NaB groups in terms of urinary microalbumin excretion in 12 weeks. All values are represented as mean ± SD, ***P<0.001. (D) H&E and PAS staining show glomerular and tubular injuries in the NC, DN and DN+NaB groups (magnification ×400).