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. 2021 Mar 13;13(3):386. doi: 10.3390/pharmaceutics13030386

Figure 2.

Figure 2

HPLC–UV chromatograms of (A) blank plasma samples; (B) blank plasma samples spiked with regorafenib (1 µg/mL) and internal standard (IS, 0.8 µg/mL); and (C) regorafenib (1.5 µg/mL) and internal standard (IS) (0.8 µg/mL) collected 180 min after regorafenib (16 mg/kg, p.o.) administration alone. Peak 1: internal standard, diethylstilbestrol. Peak 2: regorafenib. The retention time of regorafenib was 8.1 min, with good separation and no endogenous interference in the rat plasma samples, and the procedure exhibited good selectivity.