Figure 3.

The concentration versus time curves of regorafenib in the plasma of rats obtained for different time courses with or without irradiation (RT). (A) The one fraction groups included a sham group, regorafenib with RT_{0 Gy} (regorafenib × 1 d); a concurrent group treated with regorafenib 1 h after RT_{2 Gy} with 1 fraction (RT_{2 Gy × 1 f’x}); and a sequential group treated with regorafenib 24 h after RT_{2 Gy × 1 f’x}. (B) The multiple fraction treated groups included a sham group, regorafenib (p.o., q.d. × 3 d) with RT_{0 Gy} (regorafenib × 3 d); a concurrent group treated with regorafenib (p.o., q.d. × 3 d) 1 h after RT_{2 Gy} with 3 fractions (RT_{2 Gy × 3 f’x}); and a sequential group treated with regorafenib 24 h (p.o., q.d. × 3 d) after RT_{2 Gy × 3 f’x}. (C) The one fraction treatment group included a sham group, regorafenib × 1d; a concurrent group treated with regorafenib 1 h after RT_{9 Gy × 1 f’x} and a sequential group treated with regorafenib 24 h after RT_{9 Gy × 1 f’x}. (D) The multiple fraction groups included a sham group, regorafenib × 3 d; a concurrent group treated with regorafenib (p.o., q.d. × 3 d) 1 h after RT_{9 Gy × 3 f’x}; and a sequential group treated with regorafenib 24 h (p.o., q.d. × 3 d) after RT_{9 Gy × 3 f’x}. (E) The changes in the area under the concentration versus time curve (AUC) of regorafenib with or without RT. Data are expressed as the mean ± SEM (n = 6 for each group).