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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: ACS Biomater Sci Eng. 2020 Apr 17;6(5):2943–2955. doi: 10.1021/acsbiomaterials.0c00116

Figure 5. GBM1A cell death mediated by in vitro transfection with HSV-tk and ganciclovir treatment.

Figure 5.

Viability of GBM1A cells measured by MTS assay (a) in the absence of HSV-tk transfection after exposure to ganciclovir or (b-c) after HSV-tk transfection using PBAE or PEG-PBAE NPs and incubation with increasing concentrations of ganciclovir (n = 4, mean ± s.d., *: p < 0.05, statistical significance given in Table S2). Cell viability is calculated by normalizing cell counts to those of GFP-transfected cells exposed to the same concentrations of ganciclovir. (d) Representative bright-field microscopy images (scale bar = 200 μm) of GBM1A cells six days after transfection.