Fig. 8.

Diagram of the predicted mechanism of DEH treatment in colorectal cancer. Dehydrodiisoeugenol (DEH), as the monomer extracted from the Nutmeg seeds, showing an excellent anti-tumor activity to colorectal cancer both in vivo and in vitro. On the one hand, DEH can inhibit the proliferation of colorectal cancer cells via arresting cell cycle in a dose- and time-dependent manner. On the other hand, DEH cause endoplasmic reticulum (ER) stress and subsequently stimulates autophagy inhibition through the PERK-eIF2α / IRE1α-XBP-1 s-CHOP signal pathways. So as to inhibit the cell growth proliferation of colorectal cancer more effectively. Taken together, our studies suggest that DEH may be a promising therapeutic agent against colorectal cancer in the future