Table 3.
Risk factors for local recurrence by Cox proportional hazard regression analysis
| Factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Age | 0.069 | |||||
| ≤ 40 | 2.90 | 0.92–9.15 | ||||
| > 40 | 1.00 | |||||
| MRI findings | 0.520 | |||||
| Segmental lesion | 1.00 | |||||
| Isolated mass | 1.96 | 0.25–15.37 | ||||
| Histology | 0.423 | |||||
| DCIS/LCIS | 1.00 | |||||
| IDC/ILC | 0.56 | 0.13–2.34 | ||||
| Tumor size | 0.507 | |||||
| Is | 1.00 | |||||
| 1 | 0.66 | 0.15–2.95 | ||||
| 2/3 | 0.62 | 0.34–6.13 | ||||
| Nodal status | 0.294 | |||||
| − | 1.00 | |||||
| + | 1.90 | 0.57–6.32 | ||||
| Stage | 0.849 | |||||
| 0 | 1.00 | |||||
| I | 0.80 | 0.18–3.60 | ||||
| II/III | 1.18 | 0.28–4.97 | ||||
| ER | 0.482 | |||||
| + | 1.00 | |||||
| − | 1.61 | 0.42–6.04 | ||||
| PgR | 0.965 | |||||
| + | 1.00 | 0.28–3.44 | ||||
| − | 0.97 | |||||
| HER2 | 0.776 | |||||
| + | 1.00 | |||||
| − | 0.82 | 0.21–3.19 | ||||
| Subtype | 0.526 | |||||
| Luminal A-like | 1.00 | |||||
| Luminal B-like HER2 negative | 2.24 | 0.55–9.06 | ||||
| Luminal B-like HER2 positive/HER2 | 1.56 | 0.38–6.48 | ||||
| EIC | 0.927 | |||||
| + | 0.94 | 0.23–3.77 | ||||
| − | 1.00 | |||||
| Lymphatic vessel invasion | 0.005 | 0.017 | ||||
| + | 6.60 | 1.78–24.47 | 6.63 | 1.40–31.36 | ||
| − | 1.00 | |||||
| Nuclear grade | 0.518 | |||||
| Low/intermediate/high grade DCIS | 1.00 | |||||
| 1 | 0.75 | 0.12–4.60 | ||||
| 2/3 | 1.64 | 0.33–8.16 | ||||
| Operation | 0.905 | |||||
| TM/SSM | 1.00 | |||||
| NSM | 1.43 | 0.17–11.88 | ||||
| ASM | 1.44 | 0.18–11.45 | ||||
| Surgical margin (lateral) | 0.568 | |||||
| + , < 2 mm | 1.82 | 0.23–14.24 | ||||
| − | 1.00 | |||||
| Surgical margin (vertical) | 0.018 | 0.031 | ||||
| + , < 2 mm | 10.58 | 1.32–84.64 | 9.72 | 1.23–77.13 | ||
| − | 1.00 | 1.00 | ||||
| Adjuvant hormonal therapy | 0.402 | |||||
| + | 0.61 | 0.19–1.94 | ||||
| − | 1.00 | |||||
| Any chemotherapy ± Trastuzumab | 0.650 | |||||
| + | 1.31 | 0.41–4.16 | ||||
| − | 1.00 | |||||
The p-values less than 0.05 are underlined
HR, Hazard ratio; CI, Confidence Interval; MRI, Magnetic Resonance Imaging; DCIS, Ductal carcinoma in situ; LCIS, Lobular carcinoma in situ; IDC, Invasive ductal carcinoma; ILC, Invasive lobular carcinoma; EIC, Extensive intraductal component; TM: Total mastectomy; SSM: Skin-sparing mastectomy; NSM: Nipple-sparing mastectomy; ASM: Areola-sparing mastectomy; PMRT: Post-Mastectomy Radiotherapy