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. 2021 Apr 10;40:126. doi: 10.1186/s13046-021-01920-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — NLRP7 protein with high expression level in CRC promotes tumor cell proliferation and metastasis. a NLRP7 mRNA levels in CRC tissues and the normal colorectal mucosa measured by qRT-PCR. b The protein levels of NLRP7 in CRC tissues and paired normal tissues measured by WB. N: non-tumor, T: tumor. c NLRP7 protein in CRC samples and corresponding adjacent normal tissues confirmed by IHC staining. Scale bars, 100 μm. d Kaplan–Meier survival analysis of patients with CRC according to NLRP7 expression (low: score < 6, high: score ≥ 6). Knockdown and overexpression of NLRP7 affected CRC cells proliferation as determined by (e) CCK8 assay, (f) colony formation ability and (g) cell apoptosis. The results of transwell assay of the (h) migration and (i) invasion for NLRP7 knockdown and overexpression CRC cells. Scale bars, 100 μm. ***P < 0.001, **P < 0.01, and *P < 0.05. NS: no significance