Fig. 2.

Characteristic outcomes of experimental species, animal models, and species distribution in animal interventional studies. a The proportion of experimental species. 43% studies (12/28) were based on primary cells or samples from human. 32% studies (9/28) were based on primary cells or samples from mice. 14% studies (4/28) were based on primary cells or samples from rats. 11% of studies (3/28) were based on samples from canine and equinel; b Pie chart illustrating the types of animal models used in the studies. 36% the animal models were ACLT (4/11). 36% the animal models were DMM (4/11). 18% the animal models were intra-articular injection of collagenase (2/11). 9% the animal models were other animal models including osteochondral defect model (1/11); c Species distribution in interventional animal studies. 64% the interventional studies were based on mouse models. 36% the interventional studies were based on rat models