Table 2:
Regional DNA methylation analyses of controlled human exposures to diesel exhaust utilizing the exact P values
| Genomic coordinates | Gene | Software P-value | CpG sites | Position | Gene group | Relationship to CpG Island | Mean %-DNAm diesel exhaust (DE) | Mean %-DNAm clean air (CA) | Mean causal effect (ACE) | Exact P-value |
|---|---|---|---|---|---|---|---|---|---|---|
| chr5: 126 409 062–126 409 311 | C5orf63 (Clone name; FLJ44606) | 1.44 × 10−4 | cg18710053 | 126409061 | 5'UTR | Island | 24.49% | 19.21% | 5.28% | 3.91 × 10−3 |
| cg27097438 | 126409153 | First Exon | Island | 11.27% | 7.62% | 3.65% | 8.06 × 10−3 | |||
| cg22905511 | 126409198 | TSS200 | Island | 14.89% | 9.64% | 5.25% | 1.71 × 10−3 | |||
| cg10812634 | 126409211 | TSS200 | Island | 16.25% | 10.21% | 6.04% | 2.44 × 10−4 | |||
| cg02304092 | 126409227 | TSS200 | Island | 15.67% | 10.03% | 5.64% | 2.20 × 10−3 | |||
| cg21113900 | 126409308 | TSS200 | Island | 24.84% | 22.10% | 2.74% | 3.27 × 10−2 | |||
| cg15405432 | 126409310 | TSS200 | Island | 10.74% | 7.34% | 3.41% | 2.44 × 10−4 | |||
| chr15: 91 473 292–91 473 570 | UNC45A | 1.71 × 10−7 | cg03291024 | 91473291 | TSS200 | North Shore | 6.45% | 4.39% | 2.06% | 1.22 × 10−3 |
| cg08267442 | 91473386 | TSS200 | Island | 6.99% | 5.54% | 1.45% | 1.54 × 10−2 | |||
| cg01351822 | 91473475 | 5'UTR | Island | 6.17% | 3.15% | 3.03% | 9.77 × 10−4 | |||
| cg16414568 | 91473511 | 5'UTR | Island | 7.46% | 4.55% | 2.91% | 2.44 × 10−4 | |||
| cg08551047 | 91473569 | 5'UTR | Island | 18.60% | 14.57% | 4.04% | 5.13 × 10−3 |
Minimum P values are given in bold.