Table 3.
Nanofiber formulations used for the treatment of diabetic wounds in animal models
| Composition | Biomolecule | Animal Model | Area (cm2) | Time*(Days) | References |
|---|---|---|---|---|---|
| Chitosan+PVA | Desferrioxamine | Rat+diabetes 1 | 1.8 | 18 | 96 |
| — | 1 | 10 | 95 | ||
| ZnO | Rabbit+diabetes 1 | 0.28 | 12 | 97 | |
| Hyaluronic acid | AgNPs | Rat+diabetes 1 | 6.25 | 15 | 99 |
| Hyaluronic acid+collagen | VEGF, PDGF, and EGF and bFGF-loaded gelatin NPs | Rat+diabetes 1 | 1.8 | 28 | 15 |
| HPMC+PEO | Beta glucan | Mice+diabetes 2 (BKS db) | 1 | 14 | 100 |
| SF | — | Rabbit+diabetes 1 | 1.1 | 12 | 105 |
| Insulin loaded MPs | Rat+diabetes 1 | 0.8 | 14 | 104 | |
| EGF and ciprofloxacin | Rabbit+diabetes 1 | 0.3 | 14 | 102 | |
| Adipose MSC or decellularized | Mice+diabetes 2 (db/db) | 0.2 | 10 | 106 | |
| SF+PLGA | — | Rat+diabetes 1 | 3.14 | 15 (80%) | 101 |
| SF+PVA | rhEGF | Rabbit+diabetes 1 | 1.1 | 18 | 103 |
| Collagen+PLGA | rhPDGF | Rat+diabetes 1 | 0.5 | 14 | 114 |
| Glucophage | 0.5 | 14 | 115 | ||
| Collagen+PCL | Dimethyloxalyl-glycine | Rat+diabetes 1 | 2.6 | 14 | 112 |
| — | 2.6 | 14 | 111 | ||
| BG NPs | Rat+diabetes 1 | 3.1 | 21 | 113 | |
| Gelatin+PCL | Silicate-based bioceramics | Mice+diabetes 1 | 0.5 | 13 | 110 |
| PLA | Dimethyloxalylglycine-loaded MSNPs | Mice+diabetes 1 | 0.5 | 15 | 116 |
| PCL | Curcumin | Mice+diabetes 1 | 0.3 | 10 | 117 |
| Aloe vera+MSC | Mice+diabetes 2 | 0.5 | 28 | 157 | |
| Bixin | Mice+diabetes 1 | 0.2 | 14 | 119 | |
| PCL+PEG | EGF+bFGF | Mice+burn+diabetes 1 | 0.5 | 7 | 120 |
| PCL+Gum tragacanth | Curcumin+MSC | Rat+diabetes 1 | 0.8 | 15 | 118 |
| PLGA | Aloe vera+rhEGF | Mice+splinted+diabetes 2 (db/db) | 0.8 | 8 (30%) | 123 |
| rhPDGF | Rat+diabetes 1 | 0.5 | 14 | 121 | |
| Neurotensin+cellulose nanocrystals | Mice+diabetes 2 (BKS.CgDock7m./.Leprdb/JNju) | 0.3 | 14 | 122 | |
| Metformin | Rat+diabetes 1 | 0.5 | 14 | 158 | |
| PVA+curdlan | Silver nitrate | Rat+diabetes 1 | 4 | 14 | 124 |
| PLA-PEG | bFGF | Rat+diabetes 1 | 2.5 | 21 | 126 |
| RAD | — | Mice+diabetes 2 (db/db) | 0.3 | 28 | 128 |
| Heparin-mimic amphiphilic peptides | — | Mice+diabetes 2 (db/db) | 0.3 | 21 | 130 |
| Multidomain peptide (k2(SL)6k2) | — | Mice+diabetes 2 (BKS.Cg-Dock7 < m> +/+ Lepr < db>/J) | 0.5 | 14 | 129 |
Diabetes type 1 was inducted with aloxan (rabbits) or streptozocin (mice and rats) (*times for complete wound closure or more than 90% of full thickness wounds).
HPMC, hydroxypropyl methylcellulose; MP, microparticles; MSC, mesenchymal stem cell; MSNP, mesoporous silica nanoparticles; PEO, polyethylene oxide; PLA, poly(lactide); rhPDGF, recombinant human platelet-derived growth factor; SF, silk fibroin; ZnO, zinc oxide.