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. 2021 Mar 26;34(12):936–961. doi: 10.1089/ars.2020.8153

FIG. 7.

FIG. 7.

Impaired blood flow as cause of cardiac injury and heart failure in C93A mice. (A) Reactive hyperemia is significantly blunted in C93A mice, measured as elevated blood flow over basal after release of 5 min blockade of blood flow to the gastrocnemius muscle. (B) Increased mortality in C93A mice following cardiac ischemia–reperfusion. (C) Increased presence of collateral vessels from the left or right coronary artery supplying the left ventricle in C93A mice. (D) Mortality following cardiac ischemia–reperfusion occurs only in mice lacking collateral vessels. (E) Reduced cardiac output in C93A mice after acute (2 day) TAC pressure overload-induced heart failure. (F) Increased mortality in C93A mice following chronic (28 day) TAC. (G) Reduced cardiac output in C93A mice after chronic TAC. *p < 0.05 for C93 versus C93A. Replotted from Zhang et al. (135) with permission. TAC, transverse aortic constriction.