FIG. 8.

SNO-mediated regulation of ventilatory physiology. (A) Male mice lacking GSNOR (Adh5), an enzyme that reduces tissue SNO levels, lack respiratory roll-off during exposure to hypoxia (10% oxygen) since their minute ventilation fails to return to baseline like that of WT control mice. (B) C93A mice have augmented short-term potentiation of ventilation (measured as minute ventilation) following return to room air (21% oxygen) after brief hypoxia (10% oxygen). Replotted from Palmer et al. (77) (A) and Gaston et al. (26) (B), with permissions. GSNOR, glutathione-SNO reductase; WT, wild type.