Skip to main content
. Author manuscript; available in PMC: 2021 Apr 10.
Published in final edited form as: J Glaucoma. 2018 Jul;27(Suppl 1):S61–S66. doi: 10.1097/IJG.0000000000000916

Figure 2. Features of the Clusterin gene (CLU) genomic region.

Figure 2.

Clusterin gene (CLU) genomic region. The genomic location of the CLU exons (larger blue rectangles) and introns (blue lines) as depicted in the UCSC genome browser (http://ucsc.genome.edu) on chromosome 8 are shown. Beneath the exon/intron are the locations of the SNPs associated with Alzheimer disease (AD) (green type) and XFS/XFG (black type). rs2279590 is associated with both AD and XFS/XFG. The layered H3K27Ac histone marks (frequently found in regulatory regions) for 8 cell types studied by ENCODE are shown beneath the SNPs. rs3087554 and rs2279590 fall in a H3K27Ac peak in HUVEC cells (human umbilical vein). Rs3087554 and rs2279590 are also in the vicinity of a CLU miRNA binding site (miR-370) indicated in green below the H3K27Ac peaks.