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. 2020 Dec 3;59:46–61. doi: 10.1016/j.cytogfr.2020.11.003

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Fig. 4 — Arrangement of cytokines and relevant transcription factors in the human genome. Certain genes are grouped in several genomic loci positioned on chromosome 2 (IL1α, IL1β, and their receptor), 4 (CXCL 1, 2, and 10), and 17 (CCL2-7). Transcription factors STAT1 and NFκB have been mapped to chromosome 3 (STAT1) and 4 in the proximity to the CXCL cytokine gene family (NFκB). The IRF transcription factors do not form a single group and are distributed between different chromosomes. Other cytokines and their receptors highlighted in the review also do not show any spatial correlations.