Table 3.
Comparison of volumetric bone mineral density values and bone microarchitecture parameters measured by high-resolution peripheral quantitative computed tomography in the distal radius and tibia between women with pregnancy- and lactation-associated osteoporosis and the control group
| PLO | Control | P | |
|---|---|---|---|
| Distal radius | |||
| Total density, mg HA/cm3 | 240 ± 60.7 | 319.4 ± 53.5 | < .02 |
| Dtrab, mg HA/cm3 | 94.6 ± 25.8 | 143.4 ± 31.1 | < .01 |
| Dcomp, mg HA/cm3 | 852 ± 69 | 905 ± 44 | .12b |
| BV/TV, % | 7.9 ± 2.1 | 12 ± 2.6 | < .01 |
| TrabNo., 1/mm | 1.48 ± 0.23 | 1.86 ± 0.18 | .01 |
| TrabTh, mm | 0.053 ± 0.011 | 0.067 ± 0.009 | .01 |
| TrabSp, mm | 0.634 ± 0.100 | 0.473 ± 0.047a | < .01 b |
| Tb.I/N.SD, mm | 0.303 ± 0.088 | 0.191 ± 0.020a | .02c |
| Ct.Th, mm | 0.60 ± 0.14 | 0.75 ± 0.14 | .05 |
| Distal tibia | |||
| D100, mg HA/cm3 | 240 ± 66 | 285 ± 42 | .16a |
| Dtrab, mg HA/cm3 | 116 ± 31 | 142 ± 32 | .15 |
| Dcomp, mg HA/cm3 | 891 ± 61 | 919 ± 32 | .30a |
| BV/TV, % | 9.7 ± 2.6 | 11.8 ± 2.6 | .15 |
| TrabNo., 1/mm | 1.47 ± 0.20 | 1.75 ± 0.17 | .01 |
| TrabTh, mm | 0.065 ± 0.012 | 0.067 ± 0.013 | .78 |
| TrabSp, mm | 0.628 ± 0.105 | 0.508 ± 0.060 | .03a |
| Tb.I/N.SD, mm | 0.343 ± 0.116 | 0.234 ± 0.048 | .02b |
| Ct.Th, mm | 0.95 ± 0.24 | 1.11 ± 0.14 | .12b |
Nonparametric test: Wilcoxon rank sum test.
Abbreviations: BV/TV, trabecular bone volume; Ct.Th, cortical thickness; D100, total volumetric bone mineral density; Dcomp, cortical volumetric bone mineral density; Dtrab, trabecular volumetric bone mineral density; HA, hydroxyapatite; PLO, pregnancy- and lactation-associated osteoporosis; Tb.I/N.SD, bone microarchitecture heterogeneity; TrabNo., trabecular number; TrabSp, trabecular separation; TrabTh, trabecular thickness.
P = t test.
an = 7.
bDifferent variances.
cVariables with no normal distribution.