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. 2019 Apr 3;22(3):684. doi: 10.1093/biostatistics/kxz008

Table 2.

The proportion of simulations that returned significant results for each intervention effect of interest (Inline graphic)

Relative risk (Inline graphic) Test-positive fraction Odds ratio GEE Random effects
1 0.0497 0.0749 0.0779 0.0743
0.6 0.4916 0.5795 0.5936 0.6143
0.5 0.7498 0.8238 0.8266 0.8445
0.4 0.9298 0.9620 0.9603 0.9670
0.3 0.9951 0.9985 0.9983 0.9988

The GEE assumed an exchangeable correlation matrix. Each approach was applied to the results of the 10 000 random intervention allocations with 1000 cases and 4000 controls (Inline graphic).