Table 2.
Genes associated with ALS/FTD with LLPS and aggregation scores.
| Gene | LLPS score | Phase separation confirmed | Aggregation score | Found in aggregates |
|---|---|---|---|---|
| ADAR2 | 0.242 | Not yet | 98.368 | Yes |
| ANXA11 | 0.405 | Yes | 76.584 | Yes |
| ATXN2 | 0.633 | Yes | 93.428 | Yes |
| C9orf72 | 0.137 | No (DPRs only) | 99.952 | DPR yes |
| DNAJC7 | 0.289 | Not yet | 62.24 | Unknown |
| EWS | 0.857 | Yes | 4.521 | Yes |
| FUS | 0.915 | Yes | 4.473 | Yes |
| FIG4 | 0.285 | Not yet | 99.592 | Yes |
| hnRNPA1 | 0.603 | Yes | 92.027 | Yes |
| hnRNPA2B1 | 0.649 | Yes | 55.529 | Yes |
| hnRNPA3 | 0.643 | Yes | 92.132 | Yes |
| KIF5A | 0.236 | Not yet | 60.092 | Unknown |
| Matrin 3 | 0.422 | Not yet | 7.724 | Yes |
| NEK1 | 0.389 | Yes | 94.682 | Unknown |
| OPTN | 0.197 | Not yet | 79.727 | Yes |
| SOD1 | 0.223 | Not yet | 14.877 | Yes |
| SGMR1 | 0.173 | Not yet | 99.951 | Yes |
|
SYNCRIP (hnRNPQ) |
0.571 | Yes | 74.295 | Yes |
| SQSTM | 0.321 | Not yet | 6.455 | Yes |
| TARDBP | 0.376 | Yes | 97.627 | Yes |
| TAF15 | 0.801 | Yes | 4.652 | Yes |
| TIA1 | 0.422 | Yes | 47.614 | Yes |
| TBK1 | 0.194 | Not yet | 96.825 | No |
| UBQLN2 | 0.241 | Yes | 98.684 | Yes |
| VCP | 0.288 | Not yet | 61.728 | Yes |
Scores indicated in red background: highly likely to aggregate/undergo LLPS, LLPS score >0.6, aggregation score >60.
Scores indicated in orange background: likely to aggregate/undergo LLPS, LLPS score >0.3, aggregation score >40.
Scores indicated in beige background: somewhat likely to aggregate/undergo LLPS, LLPS score >0.2, aggregation score >10.
Scores indicated in white background: unlikely to aggregate/undergo LLPS, LLPS score <0.2, aggregation score <10.