Table 3.
Diagnostic efficiency of biomarkers in possible/probable/proven IPA groups.
| Cutoff value | Positive cases | Negative cases | Sensitivity% | Specificity% | PPV% | NPV% | +LR | −LR | Youden index |
| BALF GM | |||||||||
| ≥0.55 | 90 | 190 | 71.8 | 91.6 | 87.5 | 84.5 | 8.54 | 0.30 | 0.634 |
| ≥0.5 | 91 | 184 | 72.6 | 88.8 | 82.9 | 85.5 | 6.48 | 0.30 | 0.615 |
| ≥1.0 | 61 | 201 | 48.7 | 97.2 | 95.5 | 75.5 | 17.4 | 0.52 | 0.459 |
| Serum GM | |||||||||
| ≥0.5 | 28 | 200 | 22.2 | 96.6 | 95.5 | 67.4 | 6.52 | 0.80 | 0.189 |
| ≥1.0 | 14 | 206 | 11.1 | 99.4 | 99.2 | 64.9 | 18.5 | 0.89 | 0.106 |
| Serum BDG | |||||||||
| ≥10 μg/mL | 12 | 114 | 9.4 | 95.5 | 55.5 | 63.2 | 0.95 | 2.08 | 0.049 |
| ≥20 μg/mL | 8 | 201 | 6.0 | 97.2 | 46.7 | 62.9 | 0.93 | 3.36 | 0.032 |
+LR = positive likelihood ration, −LR = negative likelihood ration, BALF = bronchoalveolar lavage fluid, BDG = 1,3-β-d-glucan, GM = galactomannan, IPA = invasive pulmonary aspergillosis, NPV% = negative predictive value, ODI = optical density index, PCT = procalcitonin, PPV% = positive predictive value, Youden index = Sensitivity+ Specificity-1.
The number of possible/probable/proven IPA group was 126 and the number of no IPA group was 207.
The positive case represented the number of cases diagnosed as positive under the corresponding cutoff value.
The negative case represented the number of cases diagnosed as negative under the corresponding value.