Table 6.

Discriminatory power of biomarkers for disease activity as analyzed by the ROC curves in CD patients.

Biomarkers	Cutoff value	Youden index	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)	P-value	AUC	AUC 95%Cl
CAR	0.21	0.47	61.54	85.19	94.12	36.51	<0.001	0.766	0.665–0.867
hsCRP (mg/L)	8.92	0.39	53.70	85.19	93.55	31.51	<0.001	0.734	0.629–0.840
ALB (g/L)	36.50	0.38	48.60	89.29	94.55	31.25	<0.001	0.728	0.633–0.823
HGB (g/L)	113.50	0.42	49.54	92.86	96.43	32.10	<0.001	0.758	0.664–0.851
ESR (mm/h)	11.50	0.46	75.70	70.37	91.01	42.22	<0.001	0.769	0.676–0.863
PLT (×109/L)	246.50	0.38	59.63	78.57	91.55	33.33	<0.001	0.670	0.560–0.780
BMI (kg/m2)	23.25	0.31	81.31	50.00	87.00	39.39	<0.001	0.698	0.589–0.806

ALB = albumin, BMI = body mass index, CAR = high-sensitivity C-reactive protein/albumin ratio, CD = Crohn disease, ESR = erythrocyte sedimentation rate, HGB = hemoglobin, hsCRP = high sensitivity C reactive protein, PLT = platelet, ROC = receiver operating characteristics.