Table 2.

Cut-off values for different methods

	Derivation method	Threshold	n positive (%)	Kappa (95% CI)
Visual assessment			38 (24%)
BPND	Low K-means	0.19	41 (25%)	0.65 (0.51–0.79)
	GMM	0.23	30 (19%)	0.70 (0.57–0.84)
	High K-means	0.29	26 (16%)	0.65 (0.51–0.80)
SUVr	Low K-means	1.28	37 (23%)	0.60 (0.45–0.75)
	GMM	1.34	25 (15%)	0.63 (0.48–0.78)
	High K-means	1.43	22 (14%)	0.60 (0.44–0.75)

Cohen’s kappa was used to determine the degree of concordance between visual assessment and the six different thresholds

BP_ND binding potential, GMM Gaussian mixture modelling, SUVr standardized uptake value ratio