Table 2.
Comparison between pre-existing diagnoses in individuals with or without AL amyloidosis stratified by race.
| ICD10 code | Pre-existing diagnosis | Black, with AL N = 695 | Black, no AL N = 695 | p-value Black, AL vs not | SD | White, with AL N = 3333 | White, no AL N = 3333 | p-value White, AL vs not | SD |
|---|---|---|---|---|---|---|---|---|---|
| D47.2 | MGUS | 21.01% | 1.44% | 6.84E−31 | 0.65 | 16.41% | 0.36% | 0 | 0.61 |
| C90 | Multiple myeloma | 32.23% | 1.44% | 0 | 0.90 | 32.67% | 0.30% | 0 | 0.97 |
| Cardiac diagnoses | |||||||||
| I51.7 | Cardiomegaly | 28.92% | 9.35% | 1.81E−20 | 0.51 | 20.13% | 4.08% | 0 | 0.51 |
| I42 | Cardiomyopathy | 37.41% | 5.04% | 0 | 0.86 | 23.19% | 2.70% | 0 | 0.64 |
| I49 | Other cardiac arrhythmia | 30.50% | 10.50% | 2.59E−20 | 0.51 | 22.05% | 8.16% | 0 | 0.40 |
| R06.0 | Dyspnea | 50.07% | 21.73% | 3.24E−28 | 0.62 | 38.52% | 15.00% | 0 | 0.55 |
| R55 | Syncope and collapse | 13.53% | 7.05% | 7.1E−05 | 0.21 | 10.59% | 3.93% | 1.08E−25 | 0.26 |
| R42 | Dizziness and giddiness | 14.53% | 13.09% | 0.43694 | 0.04 | 15.51% | 9.57% | 2.43E−13 | 0.18 |
| R60 | Edema | 33.67% | 12.95% | 6.53E−20 | 0.51 | 27.69% | 7.56% | 0 | 0.55 |
| I50 | Heart failure | 54.96% | 11.94% | 0 | 1.03 | 33.00% | 5.88% | 0 | 0.73 |
| J90 | Pleural Effusion | 11.66% | 2.16% | 2.92E−12 | 0.38 | 10.08% | 1.26% | 0 | 0.39 |
| I48 | Atrial fibrillation and flutter | 22.01% | 6.04% | 1.01E−17 | 0.47 | 21.84% | 8.40% | 0 | 0.38 |
| I95 | Hypotension | 22.01% | 6.33% | 5.18E−17 | 0.46 | 17.91% | 3.57% | 0 | 0.48 |
| Renal diagnoses | |||||||||
| N04 | Nephrotic syndrome | 8.35% | 1.44% | 2.39E−09 | 0.32 | 10.08% | 0.30% | 0 | 0.45 |
| R80 | Proteinuria | 23.31% | 4.17% | 3.70E−25 | 0.58 | 19.92% | 2.13% | 0 | 0.59 |
| N18 | Chronic Kidney disease | 43.89% | 14.53% | 2.38E−33 | 0.68 | 33.15% | 6.48% | 0 | 0.71 |
| Neurological diagnoses | |||||||||
| N52.9 | Male erectile dysfunction | 7.63% | 9.07% | 0.332133 | 0.05 | 4.50% | 4.71% | 0.68 | 0.01 |
| M79.2 | Neuralgia and Neuritis | 2.30% | 3.31% | 0.255555 | 0.06 | 3% | 1.29% | 1.45E−06 | 0.12 |
| R20 | Disturbances of skin sensations | 13.96% | 8.49% | 0.001 | 0.17 | 14.13% | 7.26% | 1.13E−19 | 0.22 |
| G60 | Hereditary and idiopathic neuropathy | 12.81% | 3.02% | 1.41E−11 | 0.37 | 10.77% | 2.10% | 0 | 0.36 |
| G62 | Other and unspecified polyneuropathies | 11.66% | 4.17% | 2.38E−07 | 0.28 | 12.51% | 3.78% | 8.26E−39 | 0.32 |
| G90 | Disorders of autonomic nervous system | 2.73% | 1.44% | 0.091225 | 0.09 | 3.24% | 0.30% | 8.82E−20 | 0.22 |
| GI/hepatic | |||||||||
| R13.1 | Dysphagia | 12.81% | 6.19% | 2.57E−05 | 0.23 | 9.84% | 5.19% | 5.99E−13 | 0.18 |
| R16 | Hepatomegaly and splenomegaly | 5.76% | 1.73% | 7.57E−05 | 0.21 | 4.35% | 1.56% | 1.74E−11 | 0.17 |
| K76 | Other diseases of liver | 13.38% | 6.91% | 6.39E−05 | 0.22 | 9.15% | 4.56% | 1.21E−13 | 0.18 |
| R11 | Nausea and vomiting | 20% | 11.66% | 2.02E−05 | 0.23 | 15.51% | 7.29% | 4.61E−26 | 0.26 |
| K59.0 | Constipation | 22.16% | 12.81% | 4.43E−06 | 0.25 | 14.67% | 6.45% | 9.31E−28 | 0.27 |
| R19.7 | Diarrhea | 15.54% | 6.76% | 2.01E−07 | 0.28 | 15.27% | 6.90% | 1.37E−27 | 0.27 |
| R10 | Abdominal pain | 27.63% | 24.60% | 0.20 | 0.07 | 20.16% | 17.01% | 0.001 | 0.08 |
| Other | |||||||||
| R53 | Malaise and fatigue | 30.79% | 18.56% | 1.24E−07 | 0.29 | 32.73% | 15.12% | 0 | 0.42 |
| G56.0 | Carpal Tunnel Syndrome | 11.08% | 4.17% | 1.23E−06 | 0.26 | 8.34% | 3.36% | 4.60E−18 | 0.21 |
| D69 | Purpura | 15.25% | 3.45% | 4.23E−14 | 0.41 | 12.90% | 2.82% | 0 | 0.38 |
| K14.8 | Macroglossia | 2.30% | 0% | 5.74E−05 | 0.22 | 1.44% | 0.30% | 5.40E−07 | 0.12 |
Patients matched by age, sex, and presence of diabetes mellitus.
SD standard difference.