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Transferrin receptor (TfR)-mediated transcytosis across the blood–brain barrier (BBB). The transcytosis is initiated by the binding of anti-TfR antibody conjugated on the surface of nanoparticles with the formation of endosome. Nanoparticles are transported to the brain side by membrane fusion. TfRs are then recycled to the original side also by the transport of endosome. (Created with BioRender.com at 6 March 2021).
